Hepatosplenomegaly is the enlargement of both the liver and the spleen, usually a sign of an underlying disease rather than a problem on its own.
Many people have no symptoms. Others may notice abdominal fullness, discomfort under the right or left rib cage, early fullness when eating, or general fatigue.
Imaging confirms the size of both organs, looks for an underlying cause (infection, blood disorder, liver disease, storage disorder), and checks for related findings.
Ultrasound is the first test; CT or MRI can clarify the cause when the picture is complex.
Treatment is directed at the underlying disease — infection, blood disorder, liver disease, or other systemic illness.
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