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Scan GuidesRadiotherapy

Radiotherapy scan guide

Gamma Knife:what to expect

Gamma Knife is a highly focused form of stereotactic radiosurgery used for selected brain conditions. It does not involve a surgical cut, despite the word knife.

Written by Taiwo Oluwayemisi, B.Sc Radiography
·
Medically reviewed by Olusegun Samuel Faith, M.Sc (Medical Imaging), MPH, PgDip (MRI)· Last reviewed 13 Jul 2026
In this guide7 sections
At a glanceAbout this scanBefore your appointmentDuring the scanSafety and special situationsWhen to seek urgent helpSources and summary
Reading timeAbout 3 minutes
PreparationFollow your centre's instructions
ContrastNot usually required

Your imaging centre will confirm what applies to your appointment.

Education only — not medical advice. For urgent symptoms, see a doctor.

RadFAQS explains radiology terms, scan preparation, and what patients commonly experience. It is not a diagnosis, treatment plan, or replacement for your referring doctor, radiologist, or care team. RadFAQS does not monitor this site for emergencies and cannot respond in real time. If symptoms are severe, worsening, or urgent, do not wait for a reply here — contact a healthcare professional or emergency service immediately.

Gamma Knife is a type of stereotactic radiosurgery used to treat selected problems in the brain. It uses many small radiation beams that meet at a carefully planned target.

Despite the name, there is no knife and no surgical cut. The treatment is called radiosurgery because it treats a small target very precisely.

01 · Understand the examination

About this scan

Common Indications for Gamma Knife

Your doctor may consider Gamma Knife for:

  • Small brain metastases.
  • Some benign brain tumours.
  • Acoustic neuroma or vestibular schwannoma.
  • Meningioma in selected cases.
  • Arteriovenous malformation (AVM).
  • Trigeminal neuralgia in selected cases.
  • Small targets near sensitive brain structures.
Is it brain surgery?

No. There is no opening of the skull. Some systems use a head frame fixed to the skull with pins, while others use a mask. Your centre will explain which setup they use.

What happens when I arrive?

The team confirms the target and prepares your head position. If a frame is used, local anaesthetic is given where the pins touch the scalp.

Is there any discomfort?

The radiation is painless. You may feel pressure from a head frame, discomfort from lying still, or anxiety from the setup.

Are there risks?

Risks depend on the target. They can include headache, nausea, scalp soreness, swelling around the treated area, seizures, or delayed radiation effects. Your team should explain warning symptoms before you leave.

Will the tumour disappear immediately?

Usually no. Gamma Knife often works slowly. Follow-up scans may show shrinkage, stability, or reduced activity over time.

02 · Plan ahead

Before your appointment

What exactly does Gamma Knife treat?

It treats a small target inside the head. It is not used for cancers spread throughout the whole body.

How should I prepare?

You may need MRI, CT, blood tests, and a planning review. Tell the team if you take blood thinners, have a pacemaker, have metal implants, or struggle with tight spaces.

How is the treatment performed?

You lie on the treatment couch while the machine delivers focused radiation to the target. You do not feel the radiation.

03 · On the day

During the scan

How long does Gamma Knife take?

The actual treatment may take minutes to a few hours, depending on the number and size of targets. The full visit can take longer because of imaging, planning, frame placement, and recovery.

04 · Important exceptions

Safety and special situations

Can I have Gamma Knife if I am pregnant?

Pregnancy Precaution

Tell your doctor if you are pregnant or think you might be. Gamma Knife uses radiation, so pregnancy must be discussed before treatment.

05 · Know the red flags

When to seek urgent help

When should I seek urgent help?

Seek urgent assessment for a first seizure, a prolonged seizure, new weakness, worsening confusion, loss of consciousness, repeated vomiting, or a sudden severe headache. Follow the centre's instructions for frame-pin bleeding, swelling, or signs of infection.

06 · Learn more

Sources and summary

Sources and further reading
  • National Cancer Institute: External Beam Radiation Therapy, including stereotactic radiosurgery
  • National Cancer Institute: Radiation Therapy Side Effects
Conclusion

Gamma Knife can sound frightening because of the name, but it is a focused radiation treatment, not open brain surgery. Ask whether you will have a frame or mask, how long the day may take, and what symptoms should make you call after treatment.

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Related dictionary terms

Disease

Acoustic Neuroma

An acoustic neuroma, also called a vestibular schwannoma, is a tumor on the nerve involved in hearing and balance.

Disease

Meningioma

A meningioma is a tumor that arises from the coverings around the brain or spinal cord and is often benign, though not always harmless.

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Back to Radiotherapy guides

In this guide

At a glanceAbout this scanBefore your appointmentDuring the scanSafety and special situationsWhen to seek urgent helpSources and summary